Teams of researchers from several institutions in Switzerland have found in a research project on mice that an electrospray procedure combined with an anticancer drug shrinks lung tumors by more than 80 percent in seven days.
The Swiss scientists from the University Hospital of Bern, the university of the same name, and the University of Applied Sciences Northwestern Switzerland FHNW tried the local application on aggressive lung cancer tumors in an animal model and obtained astonishing results with great clinical potential.
Every year in Switzerland, 4,500 people (10.5 percent) develop lung cancer, a type of cancer that has a high mortality rate of 19 percent. Effective treatments are either rare, not effective enough, or too risky. Systemic treatment with chemotherapies, for example, often fails to reach the target, the lung tumor. Therefore, the researchers tested the efficacy by drugs applied directly to the tumor in mice, which were divided into three groups. The actual treatment group received „cisplatin“ as the drug applied directly under the skin using the electrospray, while the comparison groups received either „cisplatin“ without the electrospray or the electrospray with isotonic saline.
The former procedure was found to be very effective, reducing 81.2 percent of tumors in just two treatments over seven days. With the use of cisplatin without electrospray procedure, there were tumor reductions of only 15 percent.
Evaluation of the analysis in the animal trial ultimately showed that the electrospray enhanced the mechanism of action by presumably increasing the uptake of the drug from the intercellular spaces. The researchers‘ conclusion is to begin clinical trials as soon as possible so that minimally invasive procedures on hard-to-reach lung tumors can be effectively treated in this way.
Source: www.heilpraxisnet.de