A team of scientists led by Professor Dr. Philip Wenzel and Prof. Dr. Thomas Münzel from the Center for Cardiology at the University Medical Center Mainz recently used data from the Gutenberg Health Study (GHS) to show that people may respond to improved drug therapy with a naturally occurring bile acid if they suffer from cardiovascular diseases.
These primarily include coronary artery disease (CAD), atherosclerosis, heart attack, stroke, thrombosis, and pulmonary embolism, which are worsened by smoking and high blood pressure (hypertension). In these affected individuals, the blood vessel regulatory mechanism is disturbed, resulting in increased hospitalizations, even death. The cardiovascular events are due to a dysfunction of the inner lining of the blood vessel (endothelium) in which a protein called tubulin-folding cofactor E (TBCE) plays a major role. TBCE gives cells shape and structure and thus positively influences functions of the endothelium. Accordingly, a deficiency or mutation of TBCE leads to stress reactions in the vascular wall of the arteries, affecting the endoplasmic reticulum – triggering end inflammatory reactions and vascular stiffness as a consequence.
Tauroursodeoxycholic acid, or TUDCA for short, as a pharmacological novelty in cardiovascular diseases, can compensate for this TBCE defect, as researchers at Mainz University Medical Center, Department of Cardiology I, found by evaluating a 14-year GHS study in people from the Rhine-Main region.
The endothelium is involved in the narrowing and widening of the vessels because the membrane consists of specialized cells. If the mechanism is then disrupted by disturbances in the protein, this also affects the blood flow of those affected, who can then suffer from cardiovascular system diseases or even die.
TUDCA as a therapeutic approach can interrupt the endothelial dysfunction and thus improve the vascular situation of the affected persons, if the promising indications of the analysis evaluation are target-oriented. Up to now, vitamins and trace elements have been thought to remedy endothelial dysfunction.
Source: www.heilpraxisnet.de